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Traditional sequential chromatography typically requires intensive hands-on user manipulation, which could hinder the reproducibility of protein purification runs. Multi-D chromatography aims to improve this process while maintaining the efficacy of the traditional workflow.

In this episode, we share tips and tricks for minimizing protein degradation during cell lysis and sample preparation.

Obtaining enough starting material to complete multiple gene expression experiments can be challenging when working with precious and limited samples. Find out how Mark Kibschull of the Lunenfeld-Tanenbaum Research Institute in Toronto determines pluripotency and differentiation of limited human embryonic stem cells using Bio-Rad’s SingleShot Cell Lysis Kit, PreAmp Supermix, and PrimePCR validated primer panels. This simplified workflow allows for the gene expression analysis of hundreds of genes from as little as 100 human embryonic stem cells, and without the cumbersome step of isolating and purifying RNA.

Traditional real-time PCR workflows often limit the number of genes that can be studied, especially when sample amounts are small. A new workflow now allows Mark Kibschull of the Lunenfeld-Tanenbaum Research Institute in Toronto to track the expression of hundreds of genes using a fraction of the starting material required by traditional methods.

Which antibody is the best to obtain a definitive and conclusive answer for my questions? How do I choose the best antibody for my purpose? These are standard questions that scientists ask time and time again. Here are a few tips to choose the most appropriate antibody for your specific application.

Suzanne Topalian was recognized in 2014 by Nature as one of “Ten People Who Mattered This Year” for her contributions in pioneering nivolumab, a programmed cell death protein-1 (PD-1) inhibitor that was recently approved in Japan for advanced melanoma treatment and that shifts the paradigm for a wide range of cancer therapies.

A look inside Julianne Zedalis’ classroom at The Bishop’s School in San Diego, CA, gives a glimpse of how a master teacher implements inquiry in her classroom. Bio-Rad’s ThINQ! Investigations enable instructors to guide students through real-world inquiry investigations. These labs meet the revised College Board curriculum requirements and are aligned to AP Biology Big Ideas; they are designed to connect inquiry to NGSS and college curricula, encouraging students to think like real scientists.

The ZOE fluorescent cell imager features an integrated digital camera and touch-screen interface that makes brightfield and multichannel fluorescence microscopy simple, fast, and intuitive. An easy-to-use alternative to the traditional inverted microscope, ZOE eliminates the complexities of multichannel fluorescence imaging by combining the ease of use of a personal tablet and the power of an inverted microscope.

“Inquiry-based” is the new buzzphrase in science education. But what do these learning practices look like on the ground? Visit one high school in Southern California and find out about this new approach to teaching science.

Using traditional fluorescence microscopes for everyday cell imaging can be frustrating, with a lot of time spent in the darkroom mastering a highly specialized piece of equipment, all to accomplish relatively simple tasks. The ZOE Fluorescent Cell Imager eliminates the complexities of cell imaging by combining the ease of use of a personal tablet with the power of an inverted microscope. Check it out.