ArticlesCell BiologyFeatured StoriesGeneral Interest

Improving CRISPR-Cas9 Gene Editing:
Tackling the HDR Inefficiency Problem

A recent publication showed that expression of a protein involved in homology-directed repair (HDR) can improve efficiency of CRISPR-Cas9 gene editing. Learn how manipulation of DNA repair pathways and improvements to gene editing workflows, such as the addition of cell sorting, can facilitate applications of CRISPR-Cas9 technology.
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ArticlesElectrophoresis/Western BlottingProtocols and Tips

Resolved — Comic Series

Follow along as a new starry-eyed graduate student learns the ins and outs of life as a research scientist, gaining valuable western blotting tips and tricks. Along for the ride are a seasoned postdoctoral fellow and traditional principal investigator.
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ArticlesDrug Discovery and DevelopmentGeneral Interest

Lab of the Future

In an effort to increase the return on investment of research and development, pharmaceutical companies are constantly looking for ways to reduce costs. One way to do this is to incorporate technology and minimize human interaction. As a result, scientists will have more time to focus on the design and analysis of experiments. How will the Lab of the Future reflect these changes?
ArticlesFeatured StoriesGeneral Interest

Active Machine Learning in Drug Discovery

Drug discovery and development are both time and resource intensive since a lot of different compounds need to be screened across a lot of different targets. See how machine learning models can be used to predict screening results and how active learning algorithms can be used to efficiently select which experiments to perform in order to build those models.
ArticlesReal-time qPCR/PCRTechnical Reports

Reference Gene Selection Using PrimePCR Plates and CFX Maestro Software

Reference gene selection and validation are very important for gene expression studies that involve different samples or experimental conditions and therefore are absolutely necessary before any further exploration. See how PrimePCR Reference Gene Selection Panels and CFX Maestro Software provide an easy-to-use system with which to select appropriate reference genes.
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Biosimilar Purification with Ion Exchange and Mixed-Mode Resins

Presented by: Randy Drevland, PhD, Senior Applications Scientist

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Dr. Drevland presents a viable alternative workflow for the development of a HUMIRA-like biosimilar using IEX and mixed-mode resins.

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The podcast series is focused on R&D informatics, introducing you to people responsible for implementing systems and technologies to a diverse set of use-cases. Join us every month to see what you can learn.
ArticlesCell BiologyFeatured Stories

GMP-Compliant Production of CAR-T Cells Using mRNA Transfection

Many patients with treatment-resistant blood cancers have found new hope in chimeric antigen receptor (CAR)-T cell therapy. But generation of CAR-T cells at clinical scale can be challenging. Find out how the Gene Pulser Xcell Electroporation System can be used to reduce costs and risks associated with clinical-scale CAR-T cell production, while maintaining GMP compliance.
ArticlesGeneral Interest

Data Integration and Visualization Approaches

Over the past several decades, research informatics (RIS) environments within BioPharma organizations have evolved dramatically, increasing the demand for simple and easy data integration and visualization. Learn about the tools available to address this need and what the future could hold.
ArticlesCell Biology

Turning Back the Clock on Mouse Neural Progenitor Cells

Is the fate of an embryonic cell determined by the age of the cell or the age of the embryo? To explore this question, researchers isolated and transplanted live neural cells from mouse embryos at different stages of development. Learn about their findings and how the S3e Cell Sorter helped achieve this incredible feat.