ArticlesDrug Discovery and DevelopmentGeneral Interest

A Novel CAR-T Cell Therapy Approach Using Fluorescence-Activated Cell Sorting and Stem Cell Transplantation

Successful chimeric antigen receptor- (CAR-) T cell therapy requires a target antigen that is unique to cancer cells. But what happens when there are no unique antigens? Researchers at Columbia University Medical Center addressed this problem by replacing healthy non-target cells with genetically modified versions lacking the CAR-T cell target. Their results, published in PNAS, may provide a new avenue for treatment of some types of cancer.
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ArticlesCell BiologyFeatured StoriesGeneral Interest

Improving CRISPR-Cas9 Gene Editing:
Tackling the HDR Inefficiency Problem

A recent publication showed that expression of a protein involved in homology-directed repair (HDR) can improve efficiency of CRISPR-Cas9 gene editing. Learn how manipulation of DNA repair pathways and improvements to gene editing workflows, such as the addition of cell sorting, can facilitate applications of CRISPR-Cas9 technology.
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The Potential for CRISPR Gene Editing in HIV
ArticlesDrug Discovery and DevelopmentFeatured Stories

The Potential for CRISPR Gene Editing in HIV

The advent of CRISPR as a gene editing tool appears to have revolutionized drug discovery and development in a very short time. CRISPR-Cas9 technology is also being utilized to target HIV, to mutate or cut out the provirus. Read about what’s new in potential treatments for HIV and the challenges facing the industry.
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