ArticlesDroplet Digital PCR (ddPCR)Drug Discovery and Development

Precise Cell and Gene Therapy Potency Quantification

Inadequate quality control assays shouldn’t limit cell and gene therapy applications. Instead, quantifying the potency of cell and gene therapies is essential for successful therapeutics. In this article, we describe multiple leading potency assays developed using Droplet Digital PCR (ddPCR) technology, including an assay that quantifies transgene integration and expression in one step.
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ArticlesDroplet Digital PCR (ddPCR)

Modernizing Gene Editing Detection with Droplet Digital PCR

Gene editing is only useful if it’s successful. Read how scientists are leveraging the unparalleled accuracy and specificity of ddPCR technology to optimize quality control in gene editing projects, including HIV detection and CAR-T cell generation.
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Generation of Recombinant Tool Antibodies to Support Cell and Gene Therapy Development

Recombinant antibodies, CAR-T Cell Therapy Development, CAR-T Cell Therapy, Monoclonal Antibody Generation, custom antibodies, cell and gene therapy development, bioanalysis, biosimilar, immunogenicity, drug monitoring, antibody drug conjugate.
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ArticlesDrug Discovery and Development

Top 8 Advantages of Electroporation in Cell and Gene Therapy

Cell and gene therapies have seen record growth due to their potential to address the underlying causes of genetic and acquired diseases. Non-viral delivery methods are increasing in popularity due to their safety, cost-effectiveness, reduction in manufacturing time, and flexibility compared to viral vector delivery methods. Electroporation is a simple, broadly applicable method capable of delivering molecules to a wide range of cell types for either cell or gene therapy. This article outlines the top advantages of using electroporation in cell and gene therapy and why it might be a good approach for your own research group.
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ArticlesDroplet Digital PCR (ddPCR)Drug Discovery and Development

Monitoring CAR T-Cell Therapy Quality with Droplet Digital PCR

The CAR T-cell manufacturing process involves high potential for variability. Learn how sensitive ddPCR assays can be used to ensure safety and efficacy.
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ArticlesDroplet Digital PCR (ddPCR)Drug Discovery and Development

CDMOs Drive Cell and Gene Therapy from Behind the Scenes

As more of the cell and gene therapies revolutionizing healthcare are approved for use, innovator companies usually get the credit. But many therapies would never make it to market without the expertise and capabilities of contract development and manufacturing organizations (CDMOs) operating behind the scenes. Learn more about how CDMOs enable new cell and gene therapies to come to market, and how Droplet Digital PCR can help.
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ArticlesCOVID-19Droplet Digital PCR (ddPCR)

Top 5 Takeaways from ddPCR World 2021

Precision diagnostics for cancer. COVID-19 surveillance in wastewater. Quality control of cell and gene therapies. These were just a few of the cutting-edge applications on display at the Droplet Digital PCR (ddPCR) World 2021 symposium. Recapping the event in 5 takeaways, moderator Francisco Bizouarn shares how international experts are leveraging ddPCR technology to solve today’s scientific and public health problems.
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Success and QC in Cell and Gene Therapy
ArticlesDroplet Digital PCR (ddPCR)Drug Discovery and Development

With Cell and Gene Therapies, Success and Quality Control Go Hand-in-Hand

While the FDA has approved Abecma, the first CAR-T cell therapy in its class, regulatory approval is just the beginning for cell and gene therapies. Such therapies’ safety and financial viability rest on a robust manufacturing and quality control program with the flexibility to scale up and out. Droplet Digital PCR is a sensitive biopharmaceutical quality control tool, offering absolute quantification of nucleic acids and other molecules in a sample.
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