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Targeting Suppression of B-Cell Lymphoma Proliferation

Rossi considers the discovery of RNAi as pivotal to antiviral discovery. “RNAi has become another important, powerful genetic tool we can use to further our antiviral work,” he says. Rossi’s lab became the first to publish research demonstrating the expression of small interfering RNAs (siRNAs) to inhibit HIV replication in human cells. Various aspects of RNAi and siRNAs continue to play a key role in his research on viral diseases and lymphomas.