mAb Purification Process Development Using Mixed-Mode Resins — The DOE Approach
In this case study, process chromatography application scientist Artur Stanczak presents a two-step mAb purification workflow, comparing multimodal resin alternatives used for the polishing step that occurs after protein A capture. The design of experiment (DOE) data presented characterizes the behavior of multiple mAbs with two different mixed-mode resins. The importance of scale, prior knowledge, and the stage of development will also be discussed. The results of both mixed-mode resin studies and the different DOE approaches demonstrate the ability to achieve high-purity products.
Revolutionizing Efficacy and Safety Studies by Combining Organ-on-Chip Technology with xMAP-Based Bio-Plex Immunoassays
Discover how researchers are utilizing xMAP Multiplex Immunoassays to monitor biomarkers associated with tubular nephrotoxicity in kidney proximal tubule chips.
Mastering MIQE: How to Publish High-Quality qPCR Data
To obtain and publish the best quality qPCR data, you need to follow MIQE guidelines. See how to apply the MIQE guidelines to your experiments in this webinar.
Deciphering Cancer Cell Heterogeneity for Precision Medicine
scATAC-seq is a powerful tool for studying cancer cell heterogeneity. Watch this webinar to see how scATAC-seq can deliver greater insights to your research.
Fundamentals of Real-Time PCR: The Aftershow
In this special webinar, the presenters of our Gene Expression University: Fundamentals of Real-Time PCR series answer frequently asked questions. Watch now.
Introducing the PTC Tempo Thermal Cycler
The PTC Tempo Thermal Cycler represents the next generation of conventional PCR thermal cyclers from Bio-Rad. Engineered to maintain thermal performance, the PTC Tempo Thermal Cycler offers the flexibility to scale with your laboratory. The design features a refreshed, intuitive user interface and flexible connectivity options for streamlining protocol management. A motorized lid enables automation, taking your PCR to the next level with modern instrument control.
Efficient and Rapid Purification of E. coli–Expressed Toxin Recombinant Protein Fragments
Tetanus toxoid (TT) is a common carrier protein for conjugate vaccines, but its production is faced with significant challenges. Learn about a purification process that yields over 98% pure target protein in this video.
Assessing Viral Clearance in Early-Phase Process Development
Viral clearance studies are part of a multifaceted approach to ensure biopharmaceutical product safety. To prevent costly changes to a manufacturing process, it is important to assess each operation unit for its efficiency early on during downstream process development. See how a design of experiments (DOE) approach was utilized in this case study to investigate the effect of buffer pH and conductivity on the removal of impurities by an anion exchange (AEX) mixed-mode chromatography resin.
mAb Purification Process Development Using Mixed-Mode Resins — The DOE Approach
This webinar shows a 2-step mAb purification workflow and compares multimodal options for polishing. See how these methods can achieve high-purity products.
A Rapid, Culture-Free Method to Determine 50% Neutralization Titer (NT50) Using the ACE2-Competitive Bio-Plex Pro SARS-CoV-2 Neutralization Antibody Assay
In this webinar, see how a Bio-Plex Pro Assay could provide a high-throughput culture-free NT50 determination method for current and future SARS-CoV-2 variants.